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Exploration of Bacillus subtilis as Cell Factory For Amorphadiene Production

 Yafeng Song, Wim J. Quax

In this study, metabolic engineering strategies and fermentation optimizations were applied to improve the production of amorphadiene. The former includes increasing precursor supply and enhancing expression of heterologous Amorphadiene Synthase (ADS) in B. subtilis, and the latter explored the effects of different medium components as well as the culture conditions on amorphadiene production.