Hui Cao、Wenlong Su、Junjie Li、Bingqiang Wen、Shujun Tian、Shuchun Sun、Lu Li、Hanyang Wang、Jiexin Li
????????????????????????? (HDACi) ??????? (SCNT) ????????????????????????????????????? Scriptaid (??? HDACi) ?????????????????????????????????????????????????????????????????????????? Scriptaid ???????? (0?0.1?0.2?0.4?0.8 μmol/L) ????? (0?12?24?36?48 ??) ?????????????????SCNT??????H3???9?acH3K9??????H4???12?acH4K12???????????????????????????????????????????????G0/G1??????????????????0.2μmol/L??Scriptaid?24???????????????????????????????????????????????21/86 [24.39%] vs. 11/85 [12.91%]?P<0.05?????acH3K9?acH4K12??????????SCNT????????????P<0.05??????Scriptaid ???????????????????? G0/G1 ?????????????? (84.22% ? 75.96%?P<0.05)???????Scriptaid ??????????????SCNT ???????????? acH3K9/acH4K12 ?????? G0/G1 ????????????Scriptaid ??????????????????????????????
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