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Use of Tranexamic Acid for The Treatment of ACE Inhibitor Induced Angioedema

Ramzan Judge*, Matthew Freidel, Farhan Qadeer

Angiotensin Converting Enzyme Inhibitors (ACEI) is commonly prescribed antihypertensive agents in the United States and is generally safe and effective. However, in a small subset of the population, potentially fatal complications may arise as a result of their incidental effect of increasing bradykinin leading to angioedema. While there is no approved treatment, Tranexamic Acid (TXA) can decrease recovery time and improve outcomes by reducing the production of bradykinin. In this paper we discuss a patient case at our facility whose ACEI-Angioedema (ACEI-AE) improved after administration of TXA.