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Clinicopathological Features of Glypican 4 in Cancer: From Laboratory to Clinic

Victor Cherouvrier Hansson, Katrin Mani*

Glypicans have been subjected to extensive investigations in the area of oncology and hold substantial amount of preclinical and clinical data implying their clinicopathological implications. While some glypicans have been more thoroughly studied, a growing body of evidence reveal pivotal role of Glypican 4 (GPC4) in various cancers, particularly in terms of their prognostic value and therapeutic applications. This short communication presents an overview of recent developments on the impact of GPC4 in various human cancer types and its molecular involvements in mitogenic signaling.