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Synthesis, Characterization of novel Cu(II) complexes of isatin derivatives as potential cytotoxicity, DNA binding, cleavage and antibacterial agents

Ramadoss Gomathi , Andy Ramu

Schiff-base ligands are potential anti-cancer, anti-bacterial and anti-viral agents and this activity tends to increase in metal(II) Schiff-base complexes. Some oxindole-Schiff base copper(II) complexes have shown potential antitumor activity towards deferent cells, inducing apoptosis in a process modulated by the ligand. Here, six novel copper(II) complexes with schiff base ligands were isolated and characterized by IR, 1H-NMR, UV-visible , CV, EPR and ESI-Mass. All the complexes are soluble in DMF and DMSO. Elemental analysis and molar conductance values indicate that the complexes are non-electrolytes. All the complexes adopt octahedral geometry around the metal ions. DNA binding activities of the complexes L1-Cu to L6-Cu a spectroscopy are studied by UV-vis. and also cleavage studies of complexes have been done by agarose gel electrophoresis method. In-vitro biological activities of the free ligands and its Cu(II) complexes are screened against few Gram +ve and Gram –ve bacteria by disc diffusion technique. Cytotoxicity experiments carried out toward human Liver HepG2 cells confirmed its pro apoptosis property. Interestingly, compounds, L4-Cu and L6-Cu were found to be excellent anticancer activity against HepG2: liver cells and L4-Cu was most significant cytotoxicity activity against MAIT cells .