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Synthesis and Characterization and Biological Activities of Hydrazones

K. Kamalaker Reddy, Sayaji Rao ,Biyyala Sreedhar Rao

Hydrazones derivatives of carbonyl compounds constitute an important class of biologically active compounds. Metal complexes of Schiff bases represent an important class of coordination compounds. Schiffs base containing hetero donar atom continue to provide the interesting facts in the fields of coordination chemistry. Literature studies on hydrazones have shown that these derivatives possess a wide variety of biological activities such as anti-tumour, anti-bacterial, anti-viral, anti-hypertensive, analgesic etc. Complexes of Co(II), Ni(II) and Zu(II) with schiff base [LH2] derived from 2- hydroy – 5 – Bromo -3- Nitro acetophenone and isonictonoyl hydrazide have been synthesized and characterized on the basis of molar conductance magnetic properties, elemental analysis, infrared, 1H NMR, electronic spectra and thermo gravimetric analysis. The schiff base acts as mono basic bidentate ligand commonly co-ordinates through the oxygen atom of the deprotonated phenolic group and the nitrogen atom of azomethine group, which is confirmed by IR spectral data. Thermal analysis indicates the coordinated and lattice water molecules in the complexes which are also I.R. spectral data.