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Gene Expression Data Analysis for Stomach Cancer

Anita Vibhuti , U.M. Muddapur , V.G. Shanmuga Priya , Preeti Honagudi

Gene expression indicates the present state of the cell. Samples associated with the normal and cancer stomach tissues in Homo sapiens are collected by providing different stomach tissue query terms from GEO and ArrayExpress database. Manual curation is carried using Standard Operating Procedure (SOP) for both normal and cancerous condition. These samples are submitted to the novel algorithm developed at IBAB, Bangalore, to validate samples and identify stomach cancer specific genes. The study retrieved 1336 samples for stomach cancer condition. From 1336 samples it is known that genes expressed in stomach cancer were 12309; genes not expressed in stomach cancer were 7531. The study also retrieved 434 samples for normal stomach condition, by analyzing it is known that genes expressed in Normal stomach were 10477 and genes not expressed in Normal stomach were 9327. By comparison, 2080 genes were identified which were expressed in stomach cancer and not detected in Normal stomach tissue.