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Enhancement of Dissolution Rate and Bioavailability of Losartan by Self Micro Emulsifying Drug Delivery System: In-Vitro and In-Vivo Evaluation

Salunke Vaibhav

The objective of this study was to develop Self Micro Emulsifying Drug Delivery System (SMEDDS) to enhance the oral bio-availability of the poorly water soluble drug, Losartan. The influence of the oil, surfactant and co-surfactant types on the drug solubility and their ratios on forming efficient and stable SMEDDS were investigated in detail. The SMEDDS were characterized by morphological observation, droplet size and zeta potential determination, self-emulsification assessment, cloud point measurement, viscosity determination, refractive index, % transmittance, effect of pH of dilution media, drug content of SMEDDS of losartan and in vitro release study. The optimum formulation E1 consisted of Capmul MCM EP, Tween-80 and PEG-400 with S mix. Ratio of 1:1. In vitro release test showed a complete release of Losartan from SMEDDS in an approximately 1 hr. The absorption of Losartan from SMEDDS showed an increase in relative bioavailability compared with that of the marketed tablet formulation. Our studies demonstrated the promising use of SMEDDS for the delivery of Losartan by the oral route.