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Chemistry and Pharmacological Importance of 1,3,4-Oxadiazole Derivatives

Sharma R,  Kumar N,  Yaday R

Oxadiazole is an important heterocyclic compound containing one oxygen and two nitrogen atoms in the five membered ring. 1,3,4-oxadiazole is a versatile heterocyclic nucleus having novel molecule which attract the medicinal chemist to search a new therapeutic molecule. The present review summarizes physicochemical properties, various synthetic procedures and various pharmacological activities of 1,3,4-oxadiazole moiety. 1,3,4-oxadiazole moiety is an important pharmacophore which plays a major role in the pharmaceutical chemistry and broad range of important biological activities such as anti-inflammatory, analgesic, ulcerogenic, antimicrobial, antifungal antitubercular, anticonvulsant, anticancer/antitumor, antiviral, and antihypertensive activities etc. as reported in the literature.