抽象的な

RP-HPLC ????????????????? HCL???????????????????????????????: ??????????

ラマンラール N. カチャベ、アシュヴィニ T. ヴァルンガセ、プラガティ B. マンドリク、スネハル R. ワクチョーレ

???????????????????? (PAR)??????? HCl (TRM)?????????? (DOM)?????????????????????????????????????????????????????????:?????? (50:50 v/v) ?????????? 1 ml/??UV ?? 272 nm ? C18 ?????????????????????????????????????????? HCl?????????? (1 mg/kg) ?????????????????????????????????????????? HCl????????????????????? 3.3?5.3???? 8.9 ?????????????????????????????? PAR???TRM?DOM??????????250?1500?25?150?25?150 μg/mL????????????????100.12?99.87?100.4%??????????99.88?100.28?99.6%??????????PAR?TRM?DOM???????????????????????????????????HCl?????????????Cmax????????Tmax?3?4?6?156.36?335.15?55.34?ng/mL???????????3.75?5.8?4.8????????????????????????????????