抽象的な

COVID-19????????????????????????NuSepin?????????????????????II???

スンヨン・ソン、カタリナ・ルカ、コスミナ・マグダウ、オルガ・アドリアナ・カリマン＝ストゥルザ、アンドレイ・チェムルタン、スンファ・イ、ハン・スンエ

??: COVID-19 ????????????????????????????????????????????????

??:?????COVID-19 ?????????????????????? (NuSepin) ??????????????????????????????

??? 2020?9???2021?3?????????COVID-19??????????????GPCR19??????NLRP3?????????????????NuSepin?????????????????II?????????????????????????14????????????0.1 mg/kg NuSepin?0.2 mg/kg NuSepin?????????1?2??????????????????????????????14?????????????????????????TTCI?????1?????????????6???????6?????OS???????????2???????OS?????????????TTCI?=TTCI_P??????????????????????????2?NEWS2?????????????TTCI?TTCI_S?????????NEWS2=0??????????????24??????????

??? TTCI_P????????????NuSepin 0.2 mg/kg?????????mITT?????Per-Protocol?PP?????????????????1.34??95?CI?0.70?2.59??1.93??95?CI?0.96?3.85????????RR????????TTCI_S???????NuSepin 0.2 mg/kg??????????3.5??p=0.016???????NEWS2 ≥ 5?PP????????NuSepin??????????????????????RR?3.4?????????????????????????NEWS2 ≥ 5???????????NuSepin 0.2 mg/kg??????????p=0.0026??4????NuSepin 0.2 mg/kg?????52??CRP???????????????????????????20????????????????????????????????NuSepin?????????????????????????????????????NuSepin??35??60???????????11??33?????????????NuSepin 0.2 mg/kg????????1??????????????????4.5???????NuSepin????????????????????

??: (1) NuSepin ?????????????????????(2) RR ??????? NEW2=0 ??????????????(3) ????????????????????????????????????????????????? COVID-19 ??????????NuSepin 0.2 mg/kg ???????????????????????????